Reduce Media Costs with Yeast Engineering

Discover how yeast and bacteria engineering in biotechnology can significantly lower media costs, enhancing efficiency and sustainability in scientific research and production. yeast engineering

DIY GUIDES

8/17/20251 min read

photo of white staircase
photo of white staircase

Growth factors in cell culture media are extremely costs prohibitive, making it difficult for market competitors to advance. This has many consequences, such as limiting innovation in areas of research to restricting experimentation due to costs, which is dependent on competition to drive the cost down. By recombinantly expressing growth factors in cells, these problems can be solved. There are two ways to express proteins; gmo modification of cells themselves, or modification of the bacteria.

Mitogenic (induces mitosis) growth factors like FGF (Fibroblast Growth Factor) and TGF-ß constitute upwards of 95% of costs. Unfortunately, recombination expression in bacteria is difficult as these growth factors require some sort of post transnational modifications with disulfide bonds.

According to PubMed, four major GF families represented by fibroblast growth factor (FGF1 and FGF2), platelet-derived growth factor (PDGF-BB), insulin-like growth factor (IGF1 and IGF2) and transforming growth factor beta 1 (TGF-β1). These were selected as candidates for expression in E. Coli, as they are a major source of costs in cultivated meat.

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